Splenic Gene Delivery System Using Self-assembling Nano-complex with Phosphatidylserine Analog
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چکیده
منابع مشابه
Splenic gene delivery system using self-assembling nano-complex with phosphatidylserine analog.
The recognition of phosphatidylserine on the erythrocyte membrane mediates erythrophagocytosis by resident spleen macrophages. The application of phosphatidylserine to a gene vector may be a novel approach for splenic drug delivery. Therefore, we chose 1,2-dioleoyl-sn-glycero-3-phospho-L-serin (DOPS) as an analogue of phosphatidylserine for splenic gene delivery of plasmid DNA (pDNA). In the pr...
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Babak Mostaghaci1,2, Arash Hanifi3, Brigitta Loretz1 and Claus-Michael Lehr1,4 1Dept. of Drug Delivery (DDEL), Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infectious Research (HZI) Saarland University, Saarbruecken 2Biomaterials Group, Materials Engineering Department Isfahan University of Technology, Isfahan 3Tissue Imaging and Spectroscopy Lab, Bioeng...
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The design of novel proteins that self-assemble into supramolecular complexes is an important step in the development of synthetic biology and nanotechnology. Recently, we described the three-dimensional structure of WA20, a de novo protein that forms an intermolecularly folded dimeric 4-helix bundle (PDB code 3VJF ). To harness the unusual intertwined structure of WA20 for the self-assembly of...
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ژورنال
عنوان ژورنال: Biological ^|^ Pharmaceutical Bulletin
سال: 2015
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.b14-00478